Metabolismus.net

Is it really just a genes predisposition with what man ( the always hungry one ) must fight to ? Or ignorance is the main enemy? It is absolutely known that inclination to obesity is matter of inheritance but the question is whether the idea of inclination to obesity is not inexact or overestimated. Actually it’s all about metabolic imperfection, genetical abnormality, when the human body is not able of correct regulation of leptin. Leptin is a hormone which handles fat deposition.

Amount of fat depositions must be regulated and this is task for leptin. In the process of getting thicker fat cells start to enlarge themselves and produce much more leptin which comes into brain by blood and gives a signal : there is too much fat. Leptin receptors react and two changes happen: Decreasing of hunger and increase of energy for metabolism and human activity.

The more fat increasing the more leptin incoming into blood. In the properly functional metabolism the higher level of leptin in blood causes energy intake so our body would have enough energy for activity and following energy expenditure. In the case of metabolic imperfection the fat cells produce enough leptin but in brain there is not enough amount of active leptin receptors for incoming signals and therefore metabolism is not stimulated enough to expenditure of energy from consumed fat. The point is the majority of chemical signals is wasted because of not enough receptors and brain is confused and deaf to rest of the leptin signals. This is leptin resistance.

Leptin resistance is a result of two reasons. The first one is already mentioned genes predisposition. The second one is inhibition of leptin receptors caused by wrong eating manners. For example, starving whole day and big overeating in the evening. Overeating evokes fat cells to be persuaded they haven’t produced enough leptin and start to produce much more. Increased concentration of leptin in blood supercharge our brain which starts with inhibition certain amount of receptors what makes worse the problem. The result is brain deafness to leptin because of receptors inhibition, disturbance of this correlation and inhibition of whole metabolism.Brain doesn’t feel power of signals, doesn’t calm hunger down and doesn’t realize we consumed too much fat and energy and doesn’t turn it into promtly available energy. Result? Fat storing, tiredness, mental lazyness and permanent hunger. So … eat small portions but more often. It last some time till blood transports leptin to receptors and till brain signalizes satiety.